New Research at DOGenes Inc.

We have started to investigate the molecular basis of Canine Bloat (Gastric dilatation volvulus). This is being funded the Collie Health Foundation and the Samoyed Club of America Education and Research Foundation,.

We will be looking at candidate genes for this research, and will be focusing on the Collie and Samoyed breeds.

In 1987 the Morris Animal Foundation reported that there were approximately 60,000 cases of bloat in dogs in the USA with a mortality rate ranging from 7 -60 % depending on accessibility to adequate veterinary care. Clearly the understanding of this process at the molecular level and studies of the physiology of GDV are of importance to owners and breeders of purebred dogs.

Gastric dilatation - volvulus (GDV) is a life threatening condition and is found primarily in large to giant breeds. Most people know this condition as bloat. Although the exact cause of bloat is not known, it appears that this disorder may have multiple causes.

The genetics of bloat is probably complicated. An animal does not inherit bloat, but rather the predisposition to develop bloat.

Stress has been shown to be can be a risk factor. Recent kenneling or long car rides for example may cause many dogs to bloat. This research will focus on DNA sequencing genes known to be involved in the stress response.

DNA samples from Samoyeds, Collies and their relatives (especially parents, if available) are desperately needed for this research. Because the inheritance of this disorder appears to be complex, we will need as many samples as possible in order to show a statistical correlation of a mutation with the disease. The priority at the moment is to collect samples from these lines.

Participants will be asked to collect DNA cheek swab samples, and sign a transfer of ownership document for the DNA submitted.

Please do you part and get involved in this very important project! If you are willing to participate contact us at to receive your materials for participation. Participation is free.