A
-Brown Mouse -normal |
B
- Yellow mouse with insertion in promoter sequences |
C
-Chemically altered insertion causing variable phenotype |
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GENE |
Disruption of DNA that controls amount of protein produced (promoter region of the gene). |
Chemical modification (methylation) of promoter - applies to mutant genes only |
Variable chemical modification of promoter- applies to mutant genes only |
Chemical modification during embryogenesis applies to mutant genes only |
Variable phenotype |
Enviornmetal influences during embryogenesis |
Mode of inheritance |
Lower amounts of protein produced- applies to mutant genes only |
AGOUTI (Avy) |
✔ |
✔ |
✔ |
✔ |
✔ |
✔ |
Dominant with incomplete penetrance | ✔ |
COX-2 RD alleles |
✔ |
✔ |
✔ |
✔* |
✔ |
Highly probable* |
Dominant with incomplete penetrance |
Highly probable* |