Genetic Testing and
Research for Dogs
Degenerative Myelopathy type 2 (CDM2) information:
has discovered a second gene with a new mutation for Canine
degenerative myelopathy. So far this mutation has only been found in a
few breeds. Genetic testing for some of these are currently
available on our website. Many breeds have been excluded as
having this mutation. We believe that this is a dominant
mutation with variable penetrance or age of onset, however we need more
data to determine this. Our research is supported by our knowledge of
human ALS disease causing mutations.
have set up a database
to gather more information regarding breeds that may have this mutation.
purpose of this database is to determine the penetrance (% of dogs with
the CDM2 mutation that show signs of the disease). Your records can be
updated at any time. This will allow us to follow those dogs with one
or two copies of the CDM2 mutation throughout their life. This is
critical to expand our knowledge of canine degenerative myelopathy.
Owners or breeders who have dogs with clinical signs of CDM (any
breed). We still need to exclude many breeds.
Owners or breeders who have had their dogs tested for the CDM2 mutation
regardless of the result.
should be willing to update their records as the information that they
entered may change overtime.
of excluded and included breeds will be published soon.